氨基酸序列的疏水與親水的疑問
問：組成抗原表位的一些氨基酸是疏水還是親水的？為什么？還有組成信號肽的氨基酸是疏水還是親水的？為什么？
答：信號肽序列在10-40個氨基酸殘基范圍，其中部有一段長度為10-15個氨基酸殘基的由高度疏水性的氨基酸組成的肽鏈。一般蛋白質(zhì)是很難通過脂膜的，但信號肽可引導(dǎo)它通過膜到達特定的部位。
組成抗原表位的氨基酸則不一定是疏水的?？纯催@段話：
The antigenicity profile methods are based on the assumption that specific physicochemical profiles of sequences side chains, invariably corresponds with immunodominant regions of protein. Different groups have used different scales to define the antigenic potential profile along the protein sequence e.g. inverted hydrophobicity scales, scales of turns, Flexibility scales etc. The algorithms are mainly available in the form of commercial (PeptideStructure and PepPlot of GCG, Protean module of DNAstar) or freeware packages (EMBOSS, ProWin) etc.
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